Patrick Vieira’s Eagles were on their own poor run going into Sunday’s clash with Everton, which they won 3-1 courtesy of a brace from Conor Gallagher.
The Chelsea loanee will no doubt look to take centre stage again this midweek although Palace do not have the best recent record against Southampton.
A victory for the hosts could catapult them as high as eighth in the table.
Date, kick-off time and venue
Crystal Palace vs Southampton is scheduled for a 7.30pm GMT kick-off on Wednesday, December 15, 2021.
Selhurst Park in London will host the match.
Where to watch Crystal Palace vs Southampton
TV channel: The match will be televised on BT Sport 3. Coverage begins at 7.15pm.
Live stream: BT Sport subscribers will be able to watch the match online via the website or BT Sport app.
Crystal Palace vs Southampton team news
The Eagles are still waiting on the return of Joachim Andersen, who continues to struggle with a hamstring injury. If fit, the Dane may still find it difficult to dislodge James Tomkins after his goal on the weekend.
Joel Ward was fit to return versus Everton but Nathan Ferguson is out and James MacArthur yet to return from a hamstring problem.
Che Adams is out for Southampton, who also have doubts over strikers Adam Armstrong and Armando Broja. Oriol Romeu and Mohammed Salisu should return after suspension.
Willy Caballero will continue in goal if Fraser Forster again misses out, with Alex McCarthy absent along with defender Jan Bednarek.
Crystal Palace vs Southampton prediction
The Saints’ injury issues against a pretty sturdy backline could be their downfall but Palace have struggled to put teams away in recent weeks. Still, they should have enough to seal back-to-back wins.
Crystal Palace to win, 1-0.
Head to head (h2h) history and results
Southampton have lost just one of their last six meetings.