So, with Sunday’s Premier League clash with West Ham in mind, Spurs boss Nuno Espirito Santo will name a second-string side for the Group G clash at the GelreDome.
After a 1-1 draw with Rennes in their opening Europa Conference League match, Tottenham thrashed NS Mura 5-1 so have four points. Vitesse have beaten Mura and lost to Rennes in their opening two matches.
Where to watch Vitesse vs Tottenham
TV channel: Tonight’s match will be televised live on BT Sport 1, coverage starts at 5.15pm BST ahead of an 5.45pm kick-off.
Live stream: BT Sport subscribers will also be able to watch the action unfold live online via the website or through the BT Sport app.